Leonardo Jaimes, MD

All articles by Leonardo Jaimes, MD

• Ductopenia in PBC signals worse outcomes

  Losing tiny bile ducts in the liver (ductopenia) could be a strong warning sign of worse outcomes in people with PBC.

• Microbial shifts in the gut-biliary axis may drive PBC

  The gut microbiota could play a bigger role in the development of liver and biliary diseases such as PBC than what was previously thought.

• Bile duct loss at diagnosis predicts outcomes in PBC

  The amount of bile duct loss at the time of diagnosis appears to closely correlate with prognosis in patients with PBC.

• Study indicates PPAR agonists are a safe, effective treatment for PBC

  Peroxisome proliferator-activated receptor (PPAR) agonists appear to be a safe and effective therapeutic alternative for patients with PBC.

• Intercept withdraws Ocaliva from US market after evidence of liver injury

  In a postmarketing clinical trial, patients with noncirrhotic PBC receiving Ocaliva showed significantly higher rates of liver transplant and death.

• Study finds prevalence of PBC has increased globally, especially in the Western Pacific

  The Western Pacific region experienced a marked increase in PBC prevalence in the last year, notes a new study.

• Volixibat for PBC-induced itching scores breakthrough therapy designation

  The FDA gave volixibat a special approval as a potential treatment for itching in patients with primary biliary cholangitis.

• Mapping PBC genetics: Which approach is better?

  A new study suggests which method is superior for detecting genetic variables associated with primary biliary cholangitis (PCB).

• FDA approves seladelpar to treat PBC

  The U.S. Food and Drug Administration gave accelerated approval for seladelpar to treat primary biliary cholangitis (PBC).

• New insights on the role of the gut microbiome in PBC therapy 

  Changes in the gut microbiome configuration could negatively affect the response to ursodeoxycholic acid (UDCA) treatment in patients with primary biliary cholangitis (PBC), according to a recently published study in Med. “These findings suggest that baseline microbial composition may predict treatment response and offer novel insights into PBC pathogenesis,” the study concluded. UDCA represents first-line […]